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Nevertheless, the physiological role of DHARs remains uncertain, largely because the Arabidopsis triple-knockout ( dhar1 dhar2 dhar3 ) mutants that lack all three DHARs have negligible DHAR activity and display similar levels of ascorbate to the wild-type controls, with ascorbate/DHA ratios as well as plant growth and development similar to the wild type (Rahantaniaina et al

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Blood work at baseline, 12 weeks, and 24 weeks provides objective metabolic data